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Related Concept Videos

Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Immunoglobulin-like Cell Adhesion Molecules01:31

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Intracellular Signaling Affects Focal Adhesions01:17

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
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Integrins01:10

Integrins

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Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Related Experiment Video

Updated: Apr 5, 2026

The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
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The Lectin Pathway of Complement and Biocompatibility.

Estrid Hein1, Peter Garred

  • 1Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen O, Denmark.

Advances in Experimental Medicine and Biology
|August 27, 2015
PubMed
Summary

Biomaterials in health tech trigger immune responses. This review focuses on the lectin pathway of the complement system, crucial for understanding inflammatory reactions to foreign surfaces.

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Area of Science:

  • Biomedical Engineering
  • Immunology
  • Materials Science

Background:

  • The increasing use of biomaterials in medical devices like stents and implants necessitates rigorous biocompatibility assessments.
  • Foreign material surfaces interacting with blood can activate the host's immune system, particularly the complement system, leading to inflammation.

Purpose of the Study:

  • To review current data on biosurface-induced complement activation.
  • To specifically investigate the role of the lectin pathway and its initiating pattern recognition molecules in this process.

Main Methods:

  • Literature review of existing studies on complement activation by biomaterials.
  • Analysis of research focusing on the lectin pathway and its molecular triggers.

Main Results:

  • Biosurface-induced complement activation is a well-documented phenomenon.
  • The specific involvement of the lectin pathway in these responses requires further in-depth investigation.

Conclusions:

  • Understanding the lectin pathway's role is critical for developing more biocompatible medical devices.
  • Further research is needed to elucidate the precise mechanisms of lectin pathway activation by foreign surfaces.