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Updated: Apr 5, 2026
11:30
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
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Haemodialysis session: the perfect storm for vascular calcification
Miguel Seras1, Ángel Luis Martín de Francisco1, Celestino Piñera1
1Servicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, España.
Summary
Hemodialysis (HD) can cause vascular calcification (VC) in chronic kidney disease (CKD) patients due to electrolyte and acid-base imbalances, specifically calcium load and alkalization with uncontrolled phosphorus levels.
Area of Science:
- Nephrology
- Biochemistry
- Clinical Medicine
Background:
- Vascular calcification (VC) is a serious complication in chronic kidney disease (CKD), linked to mineral bone disorders and treatments.
- Hemodialysis (HD) may induce electrolyte and acid-base disturbances contributing to VC.
Purpose of the Study:
- To investigate electrolyte and acid-base disorders during HD sessions.
- To assess the impact of different calcium bath concentrations on these disorders.
Main Methods:
- Analyzed electrolyte and acid-base balance in 26 CKD patients undergoing HD.
- Patients were randomly assigned to HD with either 1.25 mM or 1.5 mM calcium bath concentrations.
Main Results:
- All patients experienced a calcium load during HD, regardless of the calcium bath concentration.
- Higher calcium bath (1.5 mM) led to hypercalcemia in 100% of patients, versus 15% with 1.25 mM.
- Phosphorus levels remained uncontrolled, and significant alkalization (increased bicarbonate and pH) occurred in all patients.
Conclusions:
- HD sessions can trigger electrolyte and acid-base disorders, including calcium load and alkalization with high phosphorus, promoting VC.
- Current HD protocols may need modification to mitigate these risks.
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