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Updated: Apr 5, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties
Ioanna Theodorou1, Parambath Anilkumar, Benoit Lelandais
1CEA, I2BM, Molecular Imaging Research Center (MIRCen), 18 route du panorama, BP no 6, 92265 Fontenay-aux-Roses, France.
Abstract:
Compact polymerized polydiacetylene-micelles with "stealth" zwitterionic surface coating were assembled and tested in a murine xenograft model of breast cancer. In vivo fluorescence imaging indicated accumulation in the tumor area and histological studies revealed predominant uptake of the micelles at the margins of the tumor, thereby allowing the delineation of its volume.
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