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Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution

Ryan McCormack1, Eckhard R Podack2

  • 1Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA.

Journal of Leukocyte Biology
|August 27, 2015
PubMed
Summary

The innate immune system evolved pore-forming proteins, like Perforin-2, to physically destroy foreign invaders. This ancient defense mechanism, crucial for eliminating microbes and infected cells, remains vital in vertebrates today.

Keywords:
MACPFbacteriacomplement

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