Interleukin-6 C-572G gene polymorphism and coronary artery disease in Asian: a meta-analysis of 2511 subjects

The interleukin-6 (IL-6) C-572G gene polymorphism has been suggested to be associated with the increased coronary artery disease (CAD) risk, but the study results are still debatable. To explore the association between IL-6 C-572G gene polymorphism and CAD in the Asian population, the current meta-analysis involving 2511 subjects from 7 separate studies was conducted. The combined odds ratio (ORs) for the association between IL-6 C-572G gene polymorphism and CAD and their corresponding 95% confidence intervals (95% CIs) were assessed by random or fixed effect model. A significant association between IL-6 C-572G gene polymorphism and CAD was found in the Asian population under an allelic (OR: 1.50, 95% CI: 1.30-1.71, P<0.00001), recessive (OR: 2.221, 95% CI: 1.444-3.417, P=1.0×10(-10)) dominant (OR: 1.313, 95% CI: 1.188-1.451, P=1.0×10(-10)), homozygous (OR: 2.454, 95% CI: 1.606-3.751, P=1.0×10(-10)), heterozygous (OR: 3.01, 95% CI:1.99-4.55, P<0.00001) and additive genetic models (OR: 1.372, 95% CI: 1.231-1.528, P=1.0×10(-10)). In the Asian population, the IL-6 C-572G gene polymorphism was indicated to be correlated with CAD susceptibility. The carriers of -572G allele might be predisposed to CAD risk.