CD14 gene-159C/T polymorphism and coronary artery disease: a meta-analysis involving 4467 subjects

Area of Science:

• Genetics
• Cardiovascular Disease Research
• Molecular Biology

Background:

• The cluster of differentiation antigen 14 (CD14) gene-159C/T polymorphism is a potential factor influencing coronary artery disease (CAD) susceptibility.
• Existing studies on the association between CD14 gene-159C/T polymorphism and CAD risk have yielded conflicting results.

Purpose of the Study:

• To conduct a comprehensive meta-analysis to clarify the relationship between the CD14 gene-159C/T polymorphism and CAD.
• To evaluate the pooled odds ratios (ORs) and confidence intervals (CIs) using random or fixed effect models.

Main Methods:

• Meta-analysis of 7 individual studies involving 4467 subjects.
• Statistical analysis using random or fixed effect models to assess pooled ORs and 95% CIs.
• Subgroup analysis was performed based on ethnicity (Chinese and Caucasian populations).

Main Results:

• A significant association was observed between CD14 gene-159C/T polymorphism and CAD across allelic, recessive, homozygous, and additive genetic models.
• No significant association was found under dominant and heterozygous genetic models.
• Subgroup analysis revealed a significant association in the Chinese population but not in the Caucasian subgroup.

Conclusions:

• The CD14 gene-159C/T polymorphism is significantly associated with CAD susceptibility, particularly in the Chinese population.
• Individuals carrying the T allele of the CD14 gene-159C/T polymorphism may have an increased predisposition to CAD.
• No clear association between this polymorphism and CAD was identified in the Caucasian subgroup.