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CD192 gene variant and susceptibility to cervical cancer: a meta analysis
Yuying Chen1, Xinli Liu2, Min Chen3
1Department of Oncology, Jiulongpo District Hospital of Traditional Chinese Medicine in Chongqing City Chongqing, China ; College of Bio-Information, Chongqing University of Posts and Telecommunications Chongqing, China.
Background:
Several molecular epidemiological studies have explored the association between G46295A variant of CD192 gene and cervical cancer susceptibility in distinct populations. However, the results are contradictory. To provide convincing evidence for the association, we performed the present meta-analysis incorporating all case-control studies.
Methods And Findings:
The Cochrane, Google Scholar and PubMed databases were systematically searched to identify the potentially relevant studies. Statistical analyses were performed using R software. Crude odds ratio (OR) was calculated to estimate the risk of cervical cancer. Five case-control studies were considered in the final analysis. Using the homozygous, heterogeneous, allele, dominant, and recessive model, we found the association between CD192 G46295A variant and cervical cancer was not statistically significant.
Conclusions:
This meta-analysis shows that the CD192 G46295A variant may not confer genetic susceptibility towards cervical cancer.
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