Related Experiment Video
Updated: Apr 5, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Personalised lamellar keratoplasty and keratopigmentation in Asian corneal leucoma patients
Xin Liu1, Jun-Hui Shen1, Qi Zhou1
1Department of Ophthalmology, Tongji Hospital Affiliated with Tongji University School of Medicine Shanghai 200065, P. R. China.
Objective:
To describe a personalised lamellar keratoplasty (LK) associated with the keratopigmentation (KTP) technique for corneal leucoma among Asian patients.
Methods:
This report was a non-randomised, retrospective clinical study performed in 32 consecutive eyes of 32 patients to improve cosmetic appearance. Twenty-two patients underwent LK combined with KTP, either by intralamellar or superficial route. Ten patients underwent the single personalised keratopigmentation method. The subjective and objective cosmetic results, ocular irritation, colour fading, neovascularisation formation and incidence of immune rejection were evaluated until three years after surgery.
Results:
No complications occurred, and the corneal leucoma was successfully stained with India ink in all 32 patients. Most of the patients showed good cosmetic appearance. Pain, conjunctival congestion, corneal edema and foreign body sensation disappeared gradually within two to three weeks after surgery in all patients. Graft swelling, non-healing, or detaching was not observed during follow-up. However, two patients had slight opacity three years after LK. Colour fading was observed in one patient who underwent intralamellar corneal staining 10 months after surgery. Re-staining was performed.
Conclusion:
KTP combined with personalised LK is an effective personalised technique that presents long-standing colour staining and good cosmetic efficacy.
