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Related Experiment Video

Updated: Apr 5, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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The association between IGF-1 polymorphisms and high myopia.

Xiaoyu Zhang1, Xingtao Zhou1, Xinhua Qu2

  • 1Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Myopia Key Laboratory of The Health Ministry Shanghai, China.

International Journal of Clinical and Experimental Medicine
|August 27, 2015
PubMed
Summary

This meta-analysis found no significant association between Insulin-like Growth Factor 1 (IGF-1) gene polymorphisms and high myopia risk. The study examined three specific IGF-1 single-nucleotide polymorphisms (SNPs) in a large cohort, concluding no genetic link to the condition.

Keywords:
IGF-1high myopiameta-analysispolymorphisms

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Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • High myopia is a complex condition with potential genetic underpinnings.
  • Previous studies suggested a link between Insulin-like Growth Factor 1 (IGF-1) gene polymorphisms and high myopia, but findings were inconsistent.
  • A comprehensive meta-analysis is needed to clarify this association.

Purpose of the Study:

  • To investigate the association between specific Insulin-like Growth Factor 1 (IGF-1) gene polymorphisms and the risk of high myopia.
  • To synthesize evidence from existing case-control and cohort studies through a meta-analysis.
  • To evaluate three common IGF-1 single-nucleotide polymorphisms (SNPs): rs6214, rs12423791, and rs5742632.

Main Methods:

  • Conducted a systematic literature search of MEDLINE, EMBASE, and OVID databases.
  • Included case-control and cohort studies investigating IGF-1 polymorphisms and high myopia.
  • Performed meta-analysis to calculate odds ratios (OR) with 95% confidence intervals (CI) for different genetic models.
  • Assessed heterogeneity, sensitivity, and publication bias.

Main Results:

  • The meta-analysis included approximately 2,187 high myopia cases and 1,183 controls.
  • No statistically significant association was found between the IGF-1 gene polymorphism rs6214 and high myopia risk across allelic, dominant, recessive, homozygote, and heterozygote models.
  • Similarly, no significant association was observed for IGF-1 SNPs rs12423791 and rs5742632 with high myopia risk.

Conclusions:

  • This meta-analysis found no evidence to support an association between the studied IGF-1 polymorphisms (rs6214, rs12423791, rs5742632) and the risk of developing high myopia.
  • The findings suggest that these specific genetic variations in the IGF-1 gene may not play a significant role in the pathogenesis of high myopia.
  • Further research may be warranted to explore other genetic factors or environmental influences contributing to high myopia.