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Updated: Apr 5, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

14.4K

Therapeutic challenges in renal cell carcinoma

Justin C Penticuff1, Natasha Kyprianou1

  • 1Departments of Urology, Molecular Biochemistry and Pathology, Markey Cancer Center, University of Kentucky College of Medicine Lexington, KY 50536, USA.

American Journal of Clinical and Experimental Urology
|August 27, 2015
PubMed

Insights

Advanced renal cell carcinoma (RCC) is challenging to treat. Targeted therapies, including drugs affecting VEGF and mTOR, show promise in improving survival for advanced kidney cancer patients.

Area of Science:

  • Oncology
  • Nephrology
  • Molecular Biology

Background:

  • Advanced renal cell carcinoma (RCC) presents significant resistance to conventional systemic therapies.
  • Understanding angiogenesis pathways and their interplay with genetic/metabolic factors in RCC variants is crucial.
  • The emergence of targeted therapies has transformed the treatment landscape for advanced kidney cancer.

Purpose of the Study:

  • To review current diagnostic challenges in advanced RCC.
  • To discuss mechanism-based clinical evidence for therapeutic management of advanced RCC.
  • To highlight advancements in targeted therapies for kidney cancer.

Main Methods:

  • Literature review of diagnostic approaches for advanced RCC.
  • Analysis of clinical evidence for targeted therapies (VEGF, mTOR inhibitors).
  • Discussion of surgical interventions and novel drug mechanisms in RCC treatment.

Main Results:

  • Targeted therapies targeting VEGF and mTOR have demonstrated improved patient survival and disease stabilization.
  • Advanced surgical techniques contribute to better outcomes in RCC management.
  • Elucidation of signaling pathways provides a basis for current therapeutic strategies.

Conclusions:

  • Targeted therapies represent a significant advancement in managing advanced RCC.
  • Continued research into diagnostic and therapeutic strategies is essential for improving outcomes in kidney cancer.
  • A comprehensive understanding of RCC biology underpins effective treatment selection.
Keywords:
Angiogenesisimagingrenal cancersurvival signalingtargeted therapies

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