[Research advances on relationship between ocular perfusion pressure fluctuations and glaucoma]

Intraocular pressure (IOP) is considered the main risk factor for the development and progression of glaucoma. The major treatment is to reduce the intraocular pressure. However, the damage of optic nerve may continue to progress despite lowering patients' IOP to the target levels. High ocular perfusion pressure (OPP) fluctuations could have detrimental effects in eyes with glaucoma which confirmed that vascular factor is one of the pathogenesis of glaucoma. This review article discussed the research progress of relationship between ocular perfusion pressure and glaucoma including its definition, calculation, epidemiological studies, fluctuation and autoregulation. We also discussed whether it was secondary to changes in intraocular pressure, blood pressure or both. We expect ocular perfusion pressure fluctuations could provide evidence for evaluating glaucoma progress.