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Updated: Apr 5, 2026

Retinal Pathophysiological Evaluation in a Rat Model
Published on: May 6, 2022
Molecular and Biochemical Aspects of the Retina on Refraction
Ranjay Chakraborty1, Machelle T Pardue1
1Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Abstract:
Mutant mouse models with specific visual pathway defects offer an advantage to comprehensively investigate the role of specific pathways/neurons involved in refractive development. In this review, we will focus on recent studies using mouse models that have provided insight into retinal pathways and neurotransmitters controlling refractive development. Specifically, we will examine the contributions of rod and cone photoreceptors and the ON and OFF retinal pathways to visually driven eye growth with emphasis on dopaminergic mechanisms.
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