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Correlations between female breast density and biochemical markers
Ji-Hye Kim1, Hae-Kag Lee2, Jae-Hwan Cho3
1Department of International Radiological Science, Hallym University of Graduate Studies, Republic of Korea ; Department of Radiology, Soonchunhyang University Hospital, Republic of Korea.
Journal of Physical Therapy Science
|August 28, 2015
Summary
This study identified several biochemical markers, including age, BMI, and cholesterol levels, associated with breast density in 200 women. These findings offer insights for breast cancer prevention strategies.
Area of Science:
- Biochemistry
- Radiology
- Oncology
Background:
- Breast density is a significant risk factor for breast cancer.
- Identifying biochemical markers associated with breast density can aid in risk assessment and prevention.
Purpose of the Study:
- To identify biochemical markers correlated with mammographically determined breast density.
- To establish baseline data for breast cancer prevention and early detection.
Main Methods:
- Mammography was used to classify breast density into four grades (ACR BI-RADS).
- Biochemical markers were analyzed from blood and urine tests in 200 fasting patients.
- Correlations between breast density, general characteristics, and biochemical markers were assessed.
Main Results:
- Age, height, weight, and body mass index (BMI) were associated with breast density.
- Hematological markers (hematocrit, MCH, RDW) showed correlations with breast density.
- Liver function tests (AST, ALT, ALP, γGT), uric acid, and lipid profiles (triglycerides, total cholesterol, HDL, LDL) were linked to breast density.
Conclusions:
- Several biochemical markers are significantly related to breast density.
- These findings provide foundational data for breast cancer prevention and early control efforts.
