Life-threatening bradyarrhythmia with oral phenytoin overdose
Giridharan Srinivasan1, Mukta Wyawahare1, Pratheesh George Mathen1
1Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Abstract:
We report a case of a 41-year-old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a temporary transvenous pacer for her hemodynamic instability. This life-threatening cardiotoxicity of phenytoin could have been due to its interaction with sulphonylurea. It is imperative to be aware of drug interactions, due to which, life-threatening cardiovascular manifestations following phenytoin toxicity can occur.
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