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Updated: Apr 4, 2026
Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry
Published on: October 18, 2016
Macrophage heterogeneity, phenotypes, and roles in renal fibrosis
Qi Cao1, Yiping Wang1, David C H Harris1
1Centre for Transplant and Renal Research, Westmead Millennium Institute at University of Sydney , Sydney, New South Wales, Australia.
Abstract:
Macrophages (MΦ) are highly heterogeneous cells that exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. MΦ are distributed throughout normal and diseased kidney tissue, where they have been recognized as key factors in renal fibrosis. Recent studies have identified switch of phenotype and diverse roles for MΦ in several murine models of kidney disease. In this review, we discuss macrophage heterogeneity and their involvement in renal fibrosis.
Insights
Macrophages are diverse cells crucial in kidney disease. This review explores their changing roles and heterogeneity in renal fibrosis.
Area of Science:
- Immunology
- Nephrology
- Cell Biology
Background:
- Macrophages (MΦ) are key immune cells with diverse roles in kidney tissue.
- Their heterogeneity is influenced by microenvironment, disease type, and stage.
- MΦ are recognized as critical factors in the development of renal fibrosis.
Approach:
- This review synthesizes recent findings on macrophage phenotypes and functions in kidney disease.
- It focuses on murine models to illustrate MΦ involvement in renal fibrosis.
- The discussion highlights the dynamic nature of MΦ in kidney pathology.
Key Points:
- Macrophage heterogeneity is a significant factor in kidney disease progression.
- Phenotypic switching allows MΦ to adopt distinct functional roles.
- Understanding MΦ diversity is essential for targeting renal fibrosis.
Conclusions:
- Macrophage heterogeneity and plasticity are central to renal fibrosis.
- Further research into MΦ roles can reveal novel therapeutic strategies.
- Targeting specific macrophage phenotypes may offer a way to treat kidney fibrosis.
