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Circulating CD147 predicts mortality in advanced hepatocellular carcinoma
Aimei Lee1,2, Anthony Rode3, Amanda Nicoll4
1Centenary Institute of Cancer Medicine and Cell Biology, Camperdown, New South Wales, Australia.
Journal of Gastroenterology and Hepatology
|August 28, 2015
Summary
High levels of circulating CD147 glycoprotein indicate poor survival in advanced hepatocellular carcinoma (HCC) patients. This finding suggests soluble CD147 as a potential independent prognostic marker for HCC.
Area of Science:
- Oncology
- Hepatology
- Biomarker Discovery
Background:
- The glycoprotein CD147 plays a role in tumor progression and is highly expressed in hepatocellular carcinoma (HCC).
- Advanced HCC patient outcomes are highly variable, necessitating better prognostic tools.
- Soluble CD147 is detectable in circulation and its prognostic value in HCC requires investigation.
Purpose of the Study:
- To evaluate circulating soluble CD147 levels as a prognostic marker in patients with HCC.
- To determine the association between CD147 levels and survival outcomes in HCC.
- To identify potential new prognostic measures for advanced HCC.
Main Methods:
- Measured CD147 levels in 277 patients (110 HCC, 115 chronic liver disease, 52 non-liver disease).
- Collected clinical data including etiology, tumor progression, Barcelona Clinic Liver Cancer (BCLC) stage, and treatment response.
- Stratified HCC patients into two groups based on the 75th percentile of CD147 levels (24 ng/mL).
Main Results:
- CD147 levels in HCC correlated inversely with survival (P=0.031).
- Elevated CD147 predicted poor survival in BCLC stages C and D (P=0.045).
- CD147 levels >24 ng/mL significantly diminished 90-day and 180-day survival (HR=6.1, P=0.0045 and HR=2.8, P=0.028, respectively), independent of tumor size and treatment.
Conclusions:
- Circulating CD147 serves as an independent marker for survival in advanced HCC.
- Soluble CD147 warrants further evaluation as a novel prognostic measure for identifying advanced HCC patients with poor prognosis.
