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Type 2 segmental glomangioma--Case report.

Camila Raposo Cabral1, Jayme de Oliveira Filho1, Julliene Lika Matsumoto1

  • 1Universidade de Santo Amaro, Santo Amaro, SP, BR.

Anais Brasileiros De Dermatologia
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Summary

Multiple glomangiomas, rare vascular tumors, can present from birth and spread throughout the body. Histopathological diagnosis is crucial for differentiating these asymptomatic childhood lesions from other vascular malformations.

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Area of Science:

  • Vascular Tumors
  • Dermatology
  • Genetics

Background:

  • Glomus tumors are neoplasms derived from modified perivascular cells.
  • Multiple glomangiomas, often asymptomatic and more common in childhood, can be inherited in an autosomal dominant pattern.
  • These lesions can be misdiagnosed as other vascular malformations.

Observation:

  • A case report details a patient with congenital hemangiomatous lesions on the calcaneus and wrist.
  • Lesions progressively disseminated throughout the body over a 6-year period.
  • The patient presented with type 2 segmental glomangiomatosis.

Findings:

  • The segmental manifestation is hypothesized to result from genetic mutation and loss of heterozygosity.
  • Dissemination of lesions with growth is attributed to mutations in distant skin areas.
  • Histopathological examination is essential for accurate diagnosis.

Implications:

  • This case highlights the importance of considering multiple glomangiomas in the differential diagnosis of childhood vascular lesions.
  • Understanding the genetic basis, such as loss of heterozygosity, aids in explaining lesion dissemination.
  • Conservative management is typically recommended for asymptomatic multiple glomangiomas.