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Opioid prescriptions before and after high-energy trauma
Stine T Zwisler1, Jesper Hallas2, Morten S Larsen3
1Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark; Mobile Emergency Care Unit, Department of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.
Journal of Opioid Management
|August 28, 2015
Summary
This study found no link between prior opioid use and trauma death. However, severe injuries, particularly to lower extremities, were linked to later opioid prescription redemption after trauma.
Area of Science:
- Trauma Care
- Pain Management
- Pharmacovigilance
Background:
- Opioid use prior to traumatic injury is common.
- Understanding patterns of opioid use around trauma is crucial for patient management and outcomes.
Purpose of the Study:
- To investigate the association between legal opioid use and outcomes in adult patients following high-energy trauma.
- To describe opioid prescription patterns before and after severe traumatic events.
Main Methods:
- Retrospective analysis of a trauma database linked with regional prescription data.
- Inclusion of 938 adult patients admitted to Odense University Hospital (OUH) for high-energy trauma between 2007-2008.
- Assessment of opioid prescription redemption within 6 months pre-trauma and at least 6 months post-trauma.
Main Results:
- No significant correlation was found between opioid prescription redemption within 6 months pre-trauma and mortality.
- Approximately 7% of patients redeemed opioid prescriptions post-trauma.
- Severe injuries, especially to the lower extremities, were significantly associated with post-trauma opioid prescription redemption.
Conclusions:
- Pre-trauma opioid use was not associated with increased mortality in this high-energy trauma cohort.
- Opioid prescription redemption after trauma is linked to injury severity, particularly in lower extremities.
- Further research may explore long-term opioid management strategies for trauma patients with severe injuries.
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