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Streaking artifact reduction for quantitative susceptibility mapping of sources with large dynamic range
Hongjiang Wei1, Russell Dibb2, Yan Zhou3
1Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.
NMR in Biomedicine
|August 28, 2015
Summary
A new method called STAR-QSM reduces artifacts in MRI susceptibility mapping. This technique improves image quality for various conditions, including brain bleeds and multiple sclerosis.
Area of Science:
- Medical Imaging
- Biophysics
Background:
- Quantitative susceptibility mapping (QSM) is an MRI technique measuring tissue magnetic susceptibility.
- Current QSM algorithms struggle with extreme susceptibility values, causing streaking artifacts.
Purpose of the Study:
- To develop a novel QSM algorithm to reduce streaking artifacts.
- To preserve subtle susceptibility contrast and anatomical details.
Main Methods:
- Developed a two-level QSM reconstruction algorithm (STAR-QSM).
- Tuned a regularization parameter for reconstructing diverse susceptibility values.
- Implemented STAR-QSM in STI Suite software.
Main Results:
- STAR-QSM significantly reduced streaking artifacts compared to iLSQR.
- Preserved sharp boundaries of blood vessels in mouse brains (in vivo and ex vivo).
- Demonstrated superiority in patient data with cerebral hematoma and multiple sclerosis.
Conclusions:
- STAR-QSM effectively reduces artifacts caused by large susceptibility sources.
- Maintains fine anatomical details in QSM.
- Offers improved quantification for susceptibility imaging.
