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Reference values for ultrasonograpy of peripheral nerves.

Mohammad Qrimli1,2, Hamid Ebadi3, Ari Breiner1

  • 1Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, Toronto General Hospital, University of Toronto University Health Network, 200 Elizabeth Street 5EC-309, Ontario, M5G 2C4, Canada.

Muscle & Nerve
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Summary

This study establishes reference values for peripheral nerve cross-sectional area (CSA) using high-resolution ultrasonography (HRU) in healthy adults. Findings indicate age, gender, and BMI influence nerve CSA, crucial for diagnostic applications.

Keywords:
cross-sectional areaneuropathyperipheral nervereference valuesultrasound

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Area of Science:

  • Neurology
  • Medical Imaging
  • Anatomy

Background:

  • High-resolution ultrasonography (HRU) offers detailed morphological insights into peripheral nerves.
  • Establishing normative data is essential for HRU's clinical utility.

Purpose of the Study:

  • To determine reference values for peripheral nerve cross-sectional area (CSA) using HRU.
  • To investigate the influence of demographic factors on nerve CSA.

Main Methods:

  • High-resolution ultrasonography (HRU) was performed on 100 healthy volunteers.
  • Cross-sectional area (CSA) of multiple peripheral nerves (median, radial, ulnar, fibular, tibial, sural, superficial fibular) was measured at defined anatomical sites.
  • Statistical analysis evaluated the impact of age, gender, and body mass index (BMI) on nerve CSA.

Main Results:

  • Normative CSA values for various peripheral nerves in healthy subjects were established.
  • Lower limb motor nerves exhibited larger CSAs compared to sensory nerves at similar locations.
  • Nerve CSA demonstrated symmetry between corresponding nerves in the limbs.
  • Age was identified as the most significant factor affecting CSA, with gender and BMI also showing some influence.

Conclusions:

  • The study provides essential normative data for HRU assessment of peripheral nerves.
  • Age- and gender-specific reference ranges are recommended for future development of HRU as a diagnostic tool for peripheral nerve pathologies.
  • Further research is warranted to refine HRU diagnostic criteria for peripheral nerve diseases.