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Remote ischemic conditioning temporarily improves antioxidant defense.

Felipe Lobato da Silva Costa1, Renan Kleber Costa Teixeira1, Vitor Nagai Yamaki1

  • 1Laboratory for Experimental Surgery, Department of Experimental Surgery, Pará State University, Belém, Pará, Brazil.

The Journal of Surgical Research
|August 29, 2015
PubMed
Summary

Remote ischemic conditioning (RIC) temporarily boosts liver and kidney antioxidant defenses within 10 minutes, offering protection against ischemia-reperfusion injury. This protective effect is short-lived, diminishing by 60 minutes post-conditioning.

Keywords:
IschemiaIschemic postconditioningLiver failureReperfusionTransplantationTransplantation conditioning

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Area of Science:

  • Physiology
  • Surgical Research
  • Biochemistry

Background:

  • Remote ischemic conditioning (RIC) is a promising surgical strategy to mitigate ischemia-reperfusion (IR) injury by inducing protection in remote tissues.
  • The precise mechanisms underlying RIC-induced protection, particularly concerning antioxidant defenses in organs like the liver and kidney, remain incompletely understood.

Purpose of the Study:

  • To investigate whether RIC enhances the antioxidant capacity of the liver and kidney as a mechanism for protection against IR injury.
  • To determine the temporal profile of RIC-induced changes in hepatic and renal antioxidant defenses.

Main Methods:

  • Wistar rats were divided into sham, RIC 10 min, and RIC 60 min groups.
  • The RIC protocol involved three cycles of 5-minute limb ischemia followed by 5-minute reperfusion.
  • Liver and kidney tissues were harvested 10 or 60 minutes after RIC to measure total antioxidant capacity.

Main Results:

  • RIC significantly increased both liver and kidney total antioxidant capacity at 10 minutes post-conditioning compared to the sham group.
  • This enhancement in antioxidant capacity was transient, with no significant difference observed at 60 minutes after the RIC protocol.

Conclusions:

  • RIC confers a temporary, short-term enhancement of antioxidant defenses in liver and kidney cells.
  • This transient increase in antioxidant capacity is a potential mechanism by which RIC protects against subsequent IR injury.