[Cellular mechanisms of compensatory processes of the kidney in relation to the mass resected]

As a result of comparative investigation of compensatory processes in the kidneys at various degree of their resection, the most general regularities in these processes have been revealed: an initial functional strain of renal cells and their ultrastructures, the secondary increase in hypertrophy and hyperplasia of the renal cells and their organelles. The degree of manifestation of these regular reactions directly depends on the mass of the resected part of the kidney. Subtotal resection of the kidney (80%) is an operation that gets out of the limits of the organ's compensatory possibilities. A sharp decrease, up to complete disappearance of its cellular division in 2-3 weeks after the operation is of great importance. Mechanism for development of renal insufficiency is evidently connected with absence of cellular renewal against the background of their hyperfunction and their quick worn out, that is, evidently, resulted in deficiency of renal epithelium and functional defectiveness connected with it in the remained renal mass.