[Clinico-morphologic analysis of compensatory and adaptive processes of the kidneys in chronic glomerulonephritis]

Patients with different patterns of chronic glomerulonephritis (CGN) were distributed in 2 groups depending on the presence or lack of chronic renal failure (CRF). In renal biopsy specimens, the mitotic index was calculated and the comparison was made of the intensity of cell division with the degree of intracellular regeneration reactions and with the efficacy of the single-type multimodality pathogenetic therapy. None mitotic figure could be discovered in the renal tissue in all the cases of CGN complicated by CRF. In uncomplicated CGN, the patients were divided into 2 groups in terms of the intensity of cell division in the kidneys. One of the groups showed hyperplasia of the cells, whereas the other one manifested the low characteristics of the mitotic index. In the group of patients with a high level of cell division, the intracellular regeneration processes in the kidneys were more pronounced and the treatment appeared more effective. The level of cell division in renal biopsy specimens may serve as an objective diagnostic criterion for CGN and its complication by CRF.