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Updated: Apr 4, 2026
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Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
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Visual recovery following open globe injury with initial no light perception
Yong S Han1, Shaheen C Kavoussi1, Ron A Adelman1
1Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA.
Clinical Ophthalmology (Auckland, N.Z.)
|August 29, 2015
Summary
In open globe injuries, eyes with no light perception (NLP) rarely regain vision. However, a small percentage of patients with NLP after ocular trauma may experience some visual recovery, warranting discussion of potential outcomes.
Area of Science:
- Ophthalmology
- Trauma Surgery
- Regenerative Medicine
Background:
- Open globe injury (OGI) is a severe ocular trauma.
- Eyes presenting with no light perception (NLP) after OGI often have a poor prognosis.
- Understanding visual outcomes and prognostic indicators is crucial for patient management.
Purpose of the Study:
- To analyze eyes with NLP following OGI.
- To determine visual outcomes in these patients.
- To identify prognostic indicators for visual recovery.
Main Methods:
- Retrospective review of consecutive patients with OGI and NLP.
- Data collected included demographics, injury characteristics, and surgical interventions.
- Statistical analysis using unpaired t-tests and Fisher's Exact tests.
Main Results:
- Twenty-five patients were included, with a mean age of 50.4 years.
- Only 16% (4 patients) regained vision (hand motion or light perception).
- 84% (21 patients) remained NLP or had a prosthesis; 56% of eyes were enucleated.
Conclusions:
- Some vision recovery is possible even in eyes with NLP after OGI.
- Physicians should discuss the potential for visual recovery in select cases.
- Further research may identify better prognostic indicators.
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