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The relationship between eosinophilia and slow coronary flow
Yakup Altas1, Ertugrul Kurtoglu2, Baris Yaylak1
1Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital, Malatya, Turkey.
Therapeutics and Clinical Risk Management
|August 29, 2015
Summary
Patients with slow coronary flow (SCF) have higher blood eosinophil counts. Elevated eosinophils may contribute to SCF development, suggesting a potential diagnostic marker.
Area of Science:
- Cardiology
- Hematology
- Inflammation Research
Background:
- Slow coronary flow (SCF) pathophysiology involves atherosclerosis, small vessel dysfunction, platelet disorders, and inflammation.
- Eosinophils are implicated in inflammation, vasoconstriction, thrombosis, and endothelial dysfunction.
Purpose of the Study:
- To investigate the association between elevated eosinophil counts (eosinophilia) and slow coronary flow (SCF).
Main Methods:
- Retrospective analysis of 6,832 patients undergoing coronary angiography from January 2011 to December 2013.
- Comparison of 102 SCF patients with 77 control subjects regarding baseline characteristics and hematological parameters.
Main Results:
- Patients with SCF exhibited significantly higher eosinophil counts compared to controls (0.24±0.17×10(3)/μL vs 0.16±0.15×10(3)/μL, P=0.002).
- Eosinophil count positively correlated with thrombolysis in myocardial infarction (TIMI) frame count in the SCF group (r=0.3, P<0.01).
Conclusions:
- Higher blood eosinophil counts are observed in patients with slow coronary flow.
- Eosinophilia may play a significant role in the pathogenesis of SCF and could serve as an indicator for its presence.
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