Related Experiment Video
Updated: Apr 4, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Macular Bruch's Membrane Length and Axial Length. The Beijing Eye Study
Jost B Jonas1, Ya Xing Wang2, Qi Zhang2
1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Germany.
Macular Bruch's membrane length (MacBMLength) does not significantly increase with axial length in myopia. Axial elongation primarily affects fovea-optic disc distance through changes in the parapapillary gamma zone, not macular Bruch's membrane.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Myopia Research
Background:
- Axial myopia is a significant public health concern.
- Understanding the structural changes in the myopic eye is crucial for managing vision impairment.
Purpose of the Study:
- To investigate the relationship between axial length and the length of macular Bruch's membrane (MacBMLength).
- To determine if axial elongation in myopia is associated with changes in MacBMLength or other peripapillary structures.
Main Methods:
- Utilized enhanced depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT) in the Beijing Eye Study.
- Measured MacBMLength, parapapillary gamma zone width, and fovea-optic disc border distance in 322 participants.
- Assessed ocular biometric and non-ophthalmologic parameters.
Main Results:
- MacBMLength showed no significant association with axial length or other ocular/systemic parameters.
- Parapapillary gamma zone width and fovea-optic disc border distance were significantly associated with longer axial length.
- Axial elongation correlated with increased fovea-optic disc distance, influenced by gamma zone width and anterior chamber depth.
Conclusions:
- MacBMLength is largely independent of axial elongation in myopia.
- Increased fovea-optic disc distance in axial myopia is primarily attributed to the development or elongation of the parapapillary gamma zone.
