Association between serum folate level and cervical cancer: a meta-analysis

Area of Science:

• Oncology
• Nutritional Science
• Epidemiology

Background:

• Folate is essential for DNA synthesis and repair, and its deficiency may impact cellular processes relevant to cancer development.
• Cervical cancer remains a significant global health concern, with various risk factors being investigated.

Purpose of the Study:

• To evaluate the association between serum folate levels and the risk of developing cervical cancer.
• To synthesize evidence from multiple studies through a meta-analysis.

Main Methods:

• A systematic literature search was conducted across major scientific databases (PubMed, Medline, Springer, Elsevier Science Direct, Cochrane Library, Google Scholar).
• Meta-analysis was performed using Rev.Man5.1 and Stata 11.0 software, calculating Odds Ratios (OR) with 95% confidence intervals (95% CI).
• Subgroup analyses were conducted based on sample size, geographic location, and the definition of deficient serum folate levels.

Main Results:

• Six case-control studies comprising 2383 participants were included in the meta-analysis.
• Overall, a statistically significant association was found between deficient serum folate levels and an increased risk of cervical cancer.
• Subgroup analysis revealed this association was significant in Asian populations and studies with fewer than 500 participants, but not in American populations or studies with larger sample sizes.

Conclusions:

• Deficiency in serum folate levels is associated with an elevated risk of cervical cancer.
• The association appears more pronounced among Asian populations.
• Further research may be warranted to explore the specific mechanisms and population-specific risk factors.