[Detecting and evaluating hyperaluminemia in 3 dialysis centers]

We have investigated plasma aluminium level in normal conditions and after application of 40 mg of desferrioxamine per one kilogram of body weight in 101 patients with different content of aluminium in dialysate solution. At 20 to 120 months of exposure by dialysate with aluminium content higher than 20 micrograms/l in an average the plasma aluminium level reached 80 micrograms/l in an average and after desferrioxamine application 211 micrograms/l. Plasma aluminium level varied between 80 to 250 micrograms/l in 16 patients with osteomalacia proved by bone biopsy. Oral ingestion of aluminium dosed 500 mg/day may result in significantly high plasma aluminium level. Desferrioxamine test proved significant accumulation of aluminium in some cases with low level of plasma aluminium, and further proved significant accumulation of aluminium in tissues at long time desferrioxamine treatment. Plasma aluminium levels 40 to 80 micrograms/l may be of clinical relevance. Aluminium level was determined by means of atomic absorption spectroscopy in graphite furnace with the accuracy +/- 3.0 micrograms/l.