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Related Experiment Videos

[Detecting and evaluating hyperaluminemia in 3 dialysis centers].

D Balabán, J Simícková, J Kubátko

    Casopis Lekaru Ceskych
    |December 15, 1989
    PubMed
    Summary

    Elevated plasma aluminium levels are common in patients exposed to contaminated dialysate. The desferrioxamine test reveals significant aluminium accumulation in tissues, even with initially low plasma levels.

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    Genome research·2001

    Area of Science:

    • Clinical Chemistry
    • Toxicology
    • Nephrology

    Context:

    • Patients undergoing dialysis are at risk of aluminium exposure through dialysate solutions.
    • Chronic aluminium exposure can lead to toxic accumulation in tissues.
    • Osteomalacia is a known complication of aluminium toxicity.

    Purpose:

    • To investigate plasma aluminium levels in patients with varying dialysate aluminium content.
    • To assess the impact of desferrioxamine administration on plasma and tissue aluminium levels.
    • To determine the clinical relevance of specific plasma aluminium concentrations.

    Summary:

    • In 101 patients, prolonged exposure to dialysate with >20 µg/L aluminium resulted in average plasma aluminium of 80 µg/L, rising to 211 µg/L after desferrioxamine administration.

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  • Sixteen patients with biopsy-proven osteomalacia showed plasma aluminium levels ranging from 80-250 µg/L.
  • Oral aluminium intake and long-term desferrioxamine treatment can lead to significant aluminium accumulation, detectable even with initially low plasma levels.

    • Impact:

    • Plasma aluminium levels between 40-80 µg/L may indicate clinical relevance and potential toxicity.
    • The desferrioxamine test is crucial for identifying hidden aluminium burden in patients.
    • Findings highlight the importance of monitoring aluminium levels in dialysis patients and considering alternative treatments to prevent toxicity.