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[Transmission of resistance to 1st and 2d generation cephalosporins]
Abstract:
The authors investigated the incidence of transferable resistance in bacterial strains resistant to cephalosporins of the first and second generation in the course of two years in materials of the microbiological department of one of the larger district hygiene stations. They recorded the development of the first strains resistant also to cephamandol, although this antibiotic is not used at all in the above area, and in exceptional instances also resistance to cephotaxime. It was revealed that the transferable resistance to cephamandol is due to the presence of an enzyme which hydrolyzes this antibiotic. When using cephalosporins of the first generation, it is important to foresee an increasing incidence of transmitted resistance to these antibiotics and possibly some strains resistant also to cephalosporins of the second generation and in exceptional cases strains resistant to cephalosporins of the third generation.
Insights
Transferable resistance to cephalosporins is increasing in bacterial strains. This study observed resistance to cephamandol and cephotaxime, even without local antibiotic use, highlighting a growing public health concern.
Area of Science:
- Microbiology
- Antimicrobial Resistance
Context:
- Investigated transferable resistance in bacterial strains over two years.
- Utilized data from a large district hygiene station's microbiology department.
Purpose:
- To determine the incidence of transferable resistance to first and second-generation cephalosporins.
- To identify emerging resistance patterns, including to antibiotics not in local use.
Summary:
- Observed the emergence of bacterial strains resistant to cephamandol and, exceptionally, cephotaxime.
- Identified an enzyme responsible for transferable cephamandol resistance.
- Anticipated increasing transmitted resistance to first-generation cephalosporins and potential resistance to later generations.
Impact:
- Highlights the need to monitor and predict the spread of cephalosporin resistance.
- Informs strategies to combat the rising threat of antimicrobial resistance in clinical settings.