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Updated: Apr 4, 2026

Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
Chemokines and Their Receptors: Potential Therapeutic Targets for Bone Cancer Pain
Ya-Qun Zhou, Heng-Yi Gao, Xue-Hai Guan
1Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. dy0711@gmail.com.
Abstract:
Bone cancer pain (BCP) is still an intractable problem currently because the analgesic pharmacological intervention remains insufficient. Thus, the development of novel therapeutic target is critical for the treatment of BCP. Emerging evidence demonstrated that some chemokines and their receptors contribute to the induction and maintenance of BCP. In this article, we reviewed the current evidence for the role of different chemokines and their receptors (e.g. CXCL12/CXCR4, CXCL1/CXCR2, CCL2/CCR2, CCL5/CCR5, CX3CL1/CX3CR1 and CXCL10/CXCR3) in mediating BCP. By extensively understanding the involvement of chemokines and their receptors in BCP, novel therapeutic targets may be revealed for the treatment of BCP.
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