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Published on: January 22, 2020
Urine fibroblast growth factor 23 levels in hypertensive children and adolescents
Magdalena Zając, Agnieszka Rybi-Szumińska1, Anna Wasilewska
1Agnieszka Rybi-Szumińska, Department of Pediatrics and Nephrology, Medical University of Bialystok, Waszyngtona 17, 15-274, Bialystok, Poland, arszuminska@gmail.com.
Aim:
To determine the correlation of urinary fibroblast growth factor 23 (FGF23) excretion with blood pressure and calcium-phosphorus metabolism.
Methods:
The study included 42 hypertensive (17 girls) and 46 healthy children and adolescents (17 girls) aged 6-18 years admitted to the Department of Pediatrics and Nephrology, Medical University of Białystok between January 2013 and December 2013. FGF23 in urine was measured using Human Intact FGF-23 ELISA Kit.
Results:
Hypertensive participants had significantly higher urine FGF23/creatinine values than the reference group (8.65 vs 5.59 RU/mg creatinine, P=0.007). Urine FGF23/creatinine positively correlated with systolic blood pressure in all participants. In hypertensive patients, urine FGF23/creatinine positively correlated with serum calcium and negatively with serum 25(OH)D, urinary calcium, phosphorus, and magnesium.
Conclusion:
This study found that FGF23 may play an important role in the pathogenesis of hypertension in children and adolescents, but our results should be confirmed by further studies.
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