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Studying cancer metastasis: Existing models, challenges and future perspectives
Denise M S van Marion1, Urszula M Domanska2, Hetty Timmer-Bosscha1
1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Critical Reviews in Oncology/Hematology
|September 1, 2015
Summary
This review overviews cancer metastasis models, from simple cell cultures to complex patient-derived xenografts. It discusses challenges in improving these models for better clinical translation and future research directions.
Area of Science:
- Oncology
- Translational Research
Background:
- Cancer metastasis is a leading cause of mortality.
- Studying metastasis requires diverse model systems.
Purpose of the Study:
- To review existing cancer metastasis models.
- To discuss challenges and future perspectives for improving preclinical models for clinical translation.
Main Methods:
- Overview of in vitro, ex-vivo, Drosophila melanogaster, zebrafish, chicken chorioallantoic membrane (CAM), and patient-derived tumor xenografts (PDTX) models.
- Discussion of model limitations and translational challenges.
Main Results:
- Existing models vary in complexity, cost, and ability to recapitulate the complete metastasis cascade.
- Simpler models are accessible but limited; complex models like PDTX offer more but are expensive.
Conclusions:
- Improving current metastasis models is crucial for enhancing the translation of preclinical findings to clinical practice.
- Future research should focus on developing more accurate and predictive models for cancer metastasis.
Keywords:
Animal modelCancerHumanized mouse modelsIn silico modelIn vitro modelMetastasisPatient derived (tumor) xenograft modelMore Related Videos
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