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Published on: June 15, 2019
RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer
Thatchawan Thanasupawat1, Aleksandra Glogowska1, Maxwell Burg1
1Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
Abstract:
The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.
