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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Updated: May 8, 2026

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
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Published on: February 8, 2017

Special Issue "Invasion and Metastasis in Brain Cancer".

Aleksandra Glogowska1, Saeid Ghavami1,2,3,4

  • 1Department of Human Anatomy and Cell Science, Faculty of Health Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0T4, Canada.

International Journal of Molecular Sciences
|February 13, 2026
PubMed
Summary

Brain tumors infiltrate brain tissue and adapt to the central nervous system environment. This unique biological feature is shared by primary gliomas and metastatic tumors from various cancers.

Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Central Nervous System Malignancies

Background:

  • Brain tumors, including primary gliomas and metastases, exhibit invasive growth patterns.

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Last Updated: May 8, 2026

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  • These tumors adapt to the distinct microenvironment of the central nervous system (CNS).
  • Understanding this adaptation is crucial for developing effective treatments.