Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioreactor Controls-III01:22

Bioreactor Controls-III

53
Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
53
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

50
Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
50
Yeast Signaling01:28

Yeast Signaling

18.5K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
18.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Oak to Wine: Evolution, Admixture, and Adaptation of California and British Columbia Saccharomyces Cerevisiae Wine Strains.

Genome biology and evolution·2026
Same author

Synthetic cytotoxicity profiling of cohesin mutants highlights recombination-based dependencies.

DNA repair·2025
Same author

Deep structure-function analysis of the endonuclease Mus81 with dominant mutational scanning.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

DNA lesions can frequently precede DNA:RNA hybrid accumulation.

Nature communications·2025
Same author

Mining yeast diversity unveils novel targets for improved heterologous laccase production in Saccharomyces cerevisiae.

Microbial cell factories·2025
Same author

Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae.

PLoS genetics·2025
Same journal

Multi-view knowledge-guided flow subgraphs with substructure initialization for explainable DDI prediction.

Briefings in functional genomics·2026
Same journal

Genetically supported mediators linking peripheral metabolism to cerebral ischemia: a multi-omics characterization of HMGCR, TLR4, and MMP9 in angina pectoris and stroke.

Briefings in functional genomics·2026
Same journal

Language model-based self-training reduces labeled data requirements by 99% for biological sequence classification.

Briefings in functional genomics·2026
Same journal

Whole-transcriptome sequencing reveals hypoxic esophageal squamous cell carcinoma-derived migrasomes driving cancer-associated fibroblast activation.

Briefings in functional genomics·2026
Same journal

An integrative meta-analysis of SARS-CoV-2 RNA-protein interactomes identifies conserved host factors shared with other RNA viruses.

Briefings in functional genomics·2026
Same journal

Retraction and replacement of: An integrated complete-genome sequencing and systems biology approach to predict antimicrobial resistance genes in the virulent bacterial strains of Moraxella catarrhalis.

Briefings in functional genomics·2026
See all related articles

Related Experiment Video

Updated: Apr 4, 2026

Competitive Genomic Screens of Barcoded Yeast Libraries
11:59

Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

18.9K

Navigating yeast genome maintenance with functional genomics.

Vivien Measday, Peter C Stirling

    Briefings in Functional Genomics
    |September 2, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Maintaining genome integrity is crucial for life. Studies in yeast reveal how genome instability, while often detrimental, can drive evolution and cancer, highlighting key cellular pathways.

    Keywords:
    DNA damagechromosome losschromosome rearrangementgenome instabilityhigh-content screeningmutatorretrotransposition

    More Related Videos

    The Green Monster Process for the Generation of Yeast Strains Carrying Multiple Gene Deletions
    13:06

    The Green Monster Process for the Generation of Yeast Strains Carrying Multiple Gene Deletions

    Published on: December 15, 2012

    14.9K
    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
    10:39

    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

    Published on: September 17, 2020

    6.9K

    Related Experiment Videos

    Last Updated: Apr 4, 2026

    Competitive Genomic Screens of Barcoded Yeast Libraries
    11:59

    Competitive Genomic Screens of Barcoded Yeast Libraries

    Published on: August 11, 2011

    18.9K
    The Green Monster Process for the Generation of Yeast Strains Carrying Multiple Gene Deletions
    13:06

    The Green Monster Process for the Generation of Yeast Strains Carrying Multiple Gene Deletions

    Published on: December 15, 2012

    14.9K
    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
    10:39

    A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

    Published on: September 17, 2020

    6.9K

    Area of Science:

    • Molecular Biology
    • Genetics
    • Cell Biology

    Background:

    • Genome integrity is essential for all organisms, maintained through replication, DNA repair, and chromosome segregation.
    • A low level of genome instability facilitates evolutionary adaptation and is implicated in human carcinogenesis.
    • Understanding cellular pathways governing genome maintenance is critical, particularly in the context of cancer development.

    Purpose of the Study:

    • To review whole-genome approaches used in the model organism Saccharomyces cerevisiae to understand genome maintenance mechanisms.
    • To identify cellular pathways and genetic underpinnings of genome instability.
    • To highlight the role of functional genomic screens in mapping genome integrity pathways.

    Main Methods:

    • Systematic creation of mutants in all nonessential and essential genes in Saccharomyces cerevisiae.
    • Application of whole-genome approaches, including functional genomic screens.
    • Utilizing a range of genetic and cytological screening modalities to assess genome instability.

    Main Results:

    • Yeast model systems have provided foundational knowledge of eukaryotic genome maintenance.
    • Functional genomic screens have identified numerous genes involved in genome stability.
    • These studies contribute to a systems-level understanding of cellular processes regulating genome integrity.

    Conclusions:

    • Whole-genome approaches in yeast are powerful tools for dissecting the genetic basis of genome instability.
    • The findings enhance our understanding of fundamental biological pathways that maintain genome integrity.
    • This research informs studies of human diseases, particularly cancer, by revealing conserved mechanisms.