Related Experiment Video
Updated: Apr 4, 2026
Simultaneous Video-EEG-ECG Monitoring to Identify Neurocardiac Dysfunction in Mouse Models of Epilepsy
Published on: January 29, 2018
Can ECG monitoring identify seizures?
Carolina Varon1, Katrien Jansen2, Lieven Lagae2
1KU Leuven, Department of Electrical Engineering ESAT-STADIUS, Kasteelpark Arenberg 10, Leuven, Belgium; iMinds Medical IT Department, Kasteelpark Arenberg 10, Leuven, Belgium.
Background:
Seizures affect the autonomic control of the heart rate and respiration, and changes in these two variables are known to occur during, and even before the EEG onset of the seizure.
Goal:
This work aims to quantify these changes and use them to identify the ECG onset.
Methods:
Single-lead ECG signals were recorded from patients suffering from focal and generalized seizures. Two algorithms are proposed: one quantifies changes in the QRS morphology using principal component analysis, and one assesses cardiorespiratory interactions using phase rectified signal averaging.
Results:
Positive predictive values of 86.6% and 77.5% and sensitivities of 100% and 90% were achieved for focal and generalized seizures respectively.
Conclusion:
Results for focal seizures are in accordance with the literature, and detection of generalized seizures is improved after including respiratory information.
Significance:
These findings could improve monitoring systems in epilepsy, and closed-loop techniques that aim to stop seizures.
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