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Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
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Published on: May 6, 2014

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Therapeutic strategies in pneumonia: going beyond antibiotics

Holger Müller-Redetzky1, Jasmin Lienau1, Norbert Suttorp1

  • 1Dept of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.

European Respiratory Review : an Official Journal of the European Respiratory Society
|September 2, 2015
PubMed

Insights

Severe pneumonia causes lung injury via immune dysregulation. While preclinical studies show promise, effective treatments beyond antibiotics for pneumonia-induced lung failure, sepsis, and acute respiratory distress syndrome are still needed.

Area of Science:

  • Immunology
  • Pulmonology
  • Critical Care Medicine

Background:

  • Innate immune system dysregulation contributes to lung injury in severe pneumonia.
  • Breakdown of vascular barrier function, hyperinflammation, and microcirculatory failure worsen patient outcomes.
  • Current treatments for pneumonia-induced lung failure, sepsis, and ARDS are limited.

Purpose of the Study:

  • To review adjuvant therapeutic strategies for pneumonia and its complications.
  • To discuss future perspectives in treating lung failure associated with pneumonia.

Main Methods:

  • Mini-review of preclinical and experimental studies.
  • Focus on adjuvant therapies beyond antibiotics.
  • Discussion of sepsis and acute respiratory distress syndrome (ARDS) as complications.

Main Results:

  • Numerous therapeutic targets and approaches show promise in preclinical models.
  • No specific preventive or curative strategies currently exist for pneumonia-induced lung failure.
  • Adjuvant therapies are being explored for pneumonia, sepsis, and ARDS.

Conclusions:

  • Targeting innate immune dysregulation is crucial for treating severe pneumonia.
  • Further research is needed to translate preclinical findings into clinical practice.
  • Adjuvant therapies hold potential for improving outcomes in pneumonia and its severe complications.

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