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Renal cell carcinoma arising in ipsilateral duplex system.

Harsh Mohan1, Reetu Kundu1, Usha Dalal2

  • 1Department of Pathology, Government Medical College and Hospital, Chandigarh, India.

Turkish Journal of Urology
|September 2, 2015
PubMed
Summary

Congenital kidney and urinary tract anomalies, like duplex systems, are common. This study explores the rare occurrence of renal cell carcinoma in a duplex kidney, suggesting a potential link needing further research.

Keywords:
Anomaliescongenitalduplicationrenal cell carcinomaureter

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Area of Science:

  • Urology
  • Nephrology
  • Developmental Biology

Background:

  • Congenital anomalies of the kidney and urinary tract (CAKUT) represent a spectrum of conditions, with duplex systems being a frequent subtype.
  • Duplex systems, characterized by duplicated collecting systems, are often asymptomatic, but their molecular pathogenesis remains largely unknown.
  • While specific genes are implicated in CAKUT, the co-occurrence of renal cell carcinoma (RCC) with duplex systems is exceptionally rare.

Purpose of the Study:

  • To investigate the uncommon association between renal cell carcinoma and a duplex system of the kidney.
  • To highlight the need for deeper insight into the potential link between renal anomalies and malignancy.

Main Methods:

  • Case report detailing a patient with renal cell carcinoma and a duplex system.
  • Review of existing literature on CAKUT, duplex systems, and renal cell carcinoma.

Main Results:

  • The study presents a rare case of renal cell carcinoma arising within a kidney exhibiting a duplex system (duplicated pelvicalyceal system and ureters).
  • The incidence of RCC in patients with duplex systems is notably low, making this case significant.

Conclusions:

  • The co-occurrence of renal cell carcinoma and duplex systems, while rare, suggests a potential association that warrants further investigation.
  • Elucidating the molecular mechanisms underlying this association could provide new insights into both congenital anomalies and renal tumorigenesis.