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Related Experiment Video

Updated: Apr 4, 2026

Laser-induced Forward Transfer of Ag Nanopaste

Laser-induced Forward Transfer of Ag Nanopaste

Published on: March 31, 2016

Engineering fluidic delays in paper-based devices using laser direct-writing.

P J W He¹, I N Katis, R W Eason

¹Optoelectronics Research Centre, University of Southampton, Highfield, Southampton, SO17 1BJ, UK. ph3e12@soton.ac.uk.

|September 3, 2015

Summary

This summary is machine-generated.

A novel laser-direct-write method enables programmable fluid delivery in paper-based microfluidic devices. This technique precisely controls fluid delays for multi-step analytical assays, simplifying device fabrication.

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Last Updated: Apr 4, 2026

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Published on: March 31, 2016

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Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

Area of Science:

Microfluidics
Materials Science
Analytical Chemistry

Background:

Paper-based microfluidic devices offer low-cost platforms for diagnostics.
Implementing multi-step assays requires precise control over fluid transport and timing.
Existing methods for fluid control in paper devices can be complex or require specialized equipment.

Purpose of the Study:

To develop a new laser-based direct-write technique for programmable fluid delivery in paper microfluidics.
To enable the fabrication of paper devices capable of performing multi-step analytical assays.
To control fluid delays by creating hydrophobic barriers within microfluidic channels.

Main Methods:

Utilized laser-induced photopolymerization to create hydrophobic barriers in paper channels.
Adjusted laser parameters (power, scan speed) to control barrier depth and porosity.
Employed continuous wave (405 nm) and pulsed (266 nm) lasers for barrier patterning.
Fabricated flow-delaying barriers at specific locations within fluidic channels.

Main Results:

Achieved programmable fluid delays ranging from minutes to over half an hour.
Demonstrated control over fluid delay by tuning laser writing parameters.
Successfully patterned hydrophobic barriers using both continuous wave and pulsed lasers.
Showcased the ability to integrate channel and barrier fabrication into a single laser-writing process.

Conclusions:

The laser-based direct-write technique offers a versatile and rapid method for fabricating paper-based microfluidic devices.
This approach simplifies the implementation of multi-step analytical assays by providing programmable fluid delivery and precise delay control.
The technique eliminates the need for specialized operating environments or custom equipment, enhancing accessibility for paper microfluidic device development.