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Opsoclonus-myoclonus syndrome associated with multiple system atrophy
Kazumasa Shindo1, Akiko Onohara1, Takanori Hata1
1Department of Neurology, University of Yamanashi Hospital, 1110 Tamaho, Yamanashi, 409-3898 Japan.
Cerebellum & Ataxias
|September 3, 2015
Summary
Opsoclonus-myoclonus syndrome (OMS) is rarely associated with neurodegenerative disorders. This case report details a patient with advanced multiple system atrophy-parkinsonian type (MSA-P) who developed OMS, a previously undescribed association.
Area of Science:
- Neurology
- Neuroscience
Background:
- Opsoclonus-myoclonus syndrome (OMS) is typically a paraneoplastic or parainfectious neurological complication.
- Association of OMS with neurodegenerative disorders has not been previously documented.
Observation:
- A 48-year-old woman with a 5-year history of multiple system atrophy-parkinsonian type (MSA-P) presented with new-onset involuntary movements.
- The patient exhibited rapid, random, multidirectional conjugate saccades (opsoclonus) and asynchronous, arrhythmic myoclonic jerks.
Findings:
- The patient was diagnosed with advanced MSA-P associated with opsoclonus-myoclonus syndrome.
- This represents the first reported instance of OMS occurring in the context of MSA-P.
Implications:
- This finding expands the known clinical spectrum of OMS.
- It suggests a potential, previously unrecognized link between neurodegenerative processes and autoimmune or inflammatory responses manifesting as OMS.
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