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Updated: Apr 4, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
Scaling law characterizing the dynamics of the transition of HIV-1 to error catastrophe
Vipul Gupta1, Narendra M Dixit
1Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India.
Abstract:
Increasing the mutation rate, μ of viruses above a threshold, μ(c) has been predicted to trigger a catastrophic loss of viral genetic information and is being explored as a novel intervention strategy. Here, we examine the dynamics of this transition using stochastic simulations mimicking within-host HIV-1 evolution. We find a scaling law governing the characteristic time of the transition: τ ≈ 0.6/(μ - μ(c)). The law is robust to variations in underlying evolutionary forces and presents guidelines for treatment of HIV-1 infection with mutagens. We estimate that many years of treatment would be required before HIV-1 can suffer an error catastrophe.
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