Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Convergent Strategy for Factor Xa Inhibition: Synthesis, Bioinformatics, and Biological Analysis of 3,5-Disubstituted Isoxazoles.

Archiv der Pharmazie·2026
Same author

Deep eutectic solvent-assisted hydrothermal synthesis of chitosan-based nanohybrid films functionalized with silver-decorated tungsten oxide.

Physical chemistry chemical physics : PCCP·2026
Same author

Personality traits, sensation seeking, and cycling safety outcomes: A multi-country study.

Journal of safety research·2026
Same author

A Synthesis of 4-Quinolone <i>N</i>-Oxides and NMR Evidence of Their Protonation-Assisted Enolisation.

Molecules (Basel, Switzerland)·2026
Same author

Self-perceived far vision quality and night driving difficulties are not related to night myopia or visual acuity.

PloS one·2026
Same author

Smarter cycling, safer cycling? Acceptance of advanced cyclist assistance systems in 19 European countries.

Ergonomics·2025

Related Experiment Video

Updated: Apr 4, 2026

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
07:23

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group

Published on: October 10, 2016

8.7K

Copper Nanoparticles in Click Chemistry.

Francisco Alonso1, Yanina Moglie2, Gabriel Radivoy2

  • 1Instituto de Síntesis Orgánica (ISO) and Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante , Apdo. 99, 03080 Alicante, Spain.

Accounts of Chemical Research
|September 3, 2015
PubMed
Summary

Copper nanoparticles (CuNPs) enable efficient and green click chemistry reactions. Supported CuNPs offer enhanced recyclability and versatility for synthesizing triazoles, outperforming bulk copper catalysts.

More Related Videos

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
12:31

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

26.1K
Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry
07:27

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

Published on: April 9, 2021

6.1K

Related Experiment Videos

Last Updated: Apr 4, 2026

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
07:23

An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group

Published on: October 10, 2016

8.7K
Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
12:31

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

26.1K
Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry
07:27

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

Published on: April 9, 2021

6.1K

Area of Science:

  • Green Chemistry and Organic Synthesis
  • Nanocatalysis and Heterogeneous Catalysis

Background:

  • 21st-century challenges necessitate sustainable and environmentally benign scientific practices.
  • Click chemistry, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC), is a vital synthetic tool.
  • Nanocatalysis offers a green approach to enhance CuAAC efficiency and catalyst reusability.

Purpose of the Study:

  • To investigate the use of unsupported and supported copper nanoparticles (CuNPs) as catalysts in CuAAC reactions.
  • To evaluate the performance, robustness, and recyclability of CuNPs compared to traditional copper catalysts.
  • To explore the application of CuNPs in various green synthetic protocols for triazole derivatives.

Main Methods:

  • Preparation of unsupported and supported CuNPs via chemical reduction.
  • Catalysis of CuAAC reactions using CuNPs in various solvents, including water.
  • Characterization of catalytic activity, in situ reaction intermediates, and catalyst recovery/reutilization.

Main Results:

  • Unsupported CuNPs catalyzed CuAAC reactions efficiently but showed dissolution and poor recovery.
  • Supported CuNPs (CuNPs/C, magnetically recoverable CuNPs/MagSilica) demonstrated superior robustness, recyclability, and catalytic activity.
  • Supported CuNPs facilitated multicomponent reactions, reduced metal loading, enabled reactions in water, and synthesized diverse triazole structures, including β-hydroxy- and β-methylsulfanyl-1,2,3-triazoles.

Conclusions:

  • Supported CuNPs, especially CuNPs/C, are highly effective and versatile catalysts for green CuAAC reactions.
  • Nanocatalysis with supported CuNPs provides a sustainable alternative to bulk copper catalysts, offering improved yields, shorter reaction times, and enhanced recyclability.
  • This study highlights the significant utility of nanosized copper in advancing green click chemistry methodologies.