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Parathyroid hormone secretion in magnesium deficiency.
The Journal of Clinical Endocrinology and Metabolism
|October 1, 1978
Summary
Magnesium administration acutely stimulates parathyroid hormone (PTH) secretion in individuals with magnesium deficiency. This response is not observed in normal individuals or those with hyperparathyroidism, suggesting impaired PTH secretion contributes to hypocalcemia in magnesium deficiency.
Area of Science:
- Endocrinology
- Mineral Metabolism
Background:
- Hypocalcemia is often associated with magnesium deficiency.
- The role of parathyroid hormone (PTH) in this condition is not fully understood.
Purpose of the Study:
- To investigate the effect of acute magnesium elevation on serum immunoreactive parathyroid hormone (IPTH) levels.
- To differentiate the PTH response to magnesium in hypocalcemic hypomagnesemic patients versus other groups.
Main Methods:
- Serum IPTH concentrations were measured before and after magnesium administration.
- Study included hypocalcemic hypomagnesemic patients, hyperparathyroid patients, and normal individuals.
Main Results:
- Hypomagnesemic patients showed an immediate rise in serum IPTH after magnesium administration.
- Normal individuals and hyperparathyroid patients exhibited a decrease or no change in serum IPTH.
- Basal IPTH levels in hypomagnesemic patients varied significantly.
Conclusions:
- Acute magnesium administration stimulates PTH secretion in magnesium-deficient states.
- Impaired PTH secretion is a key factor in the hypocalcemia of magnesium deficiency.