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Updated: Apr 4, 2026

Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection
Published on: July 5, 2024
STAT3: a critical component in the response to Helicobacter pylori infection
Trevelyan R Menheniott1,2, Louise M Judd1,2, Andrew S Giraud1,2
1Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Abstract:
STAT3 imparts a profound influence on both the epithelial and immune components of the gastric mucosa, and through regulation of key intracellular signal transduction events, is well placed to control inflammatory and oncogenic outcomes in the context of Helicobacter (H.) pylori infection. Here we review the roles of STAT3 in the host immune response to H. pylori infection, from both gastric mucosal and systemic perspectives, as well as alluding more specifically to STAT3-dependent mechanisms that might be exploited as drug targets.
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