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Related Experiment Videos

Prolonged hyperprolactinemia in preterm infants.

M Perlman, J Schenker, M Glassman

    The Journal of Clinical Endocrinology and Metabolism
    |October 1, 1978
    PubMed
    Summary
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    Serum prolactin (PRL) levels differ between full-term and preterm infants early after birth but normalize by 4 weeks. Postnatal maturation of PRL inhibition appears to occur by 44-52 weeks postmenstrually.

    Area of Science:

    • Neonatal physiology
    • Endocrinology
    • Pediatric research

    Background:

    • Prolactin (PRL) plays a role in infant development.
    • Understanding PRL secretion patterns is crucial for assessing infant health.
    • Serial PRL measurements can reveal developmental trajectories.

    Purpose of the Study:

    • To compare serum prolactin (PRL) levels in full-term (FT) and preterm (PT) infants.
    • To investigate the postnatal maturation of PRL secretion inhibition.
    • To correlate PRL levels with postmenstrual and postnatal ages.

    Main Methods:

    • Serial serum PRL levels were measured in FT (39-41 weeks) and PT (30-32 weeks) infants.
    • Measurements were taken from birth up to 12 postnatal weeks for FT and 20 weeks for PT infants.

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  • PRL levels were analyzed based on both postnatal and postmenstrual ages.

    • Main Results:

    • On day 1, FT infants had higher PRL levels than PT infants (267 vs. 156 ng/ml).
    • PRL levels became similar in both groups by 2-4 weeks postnatally (approx. 69 ng/ml).
    • FT infants showed a decline to near-adult PRL levels by 4-12 weeks, while PT infants reached this by 12-20 weeks.

    Conclusions:

    • PRL levels exhibit distinct patterns in FT and PT infants based on postnatal age.
    • When assessed by postmenstrual age, PRL levels show similar patterns in both groups.
    • These findings suggest postnatal maturation of PRL secretion inhibition, possibly by 44-52 weeks postmenstrually.