Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lateral Temporal Brow Lift: A 20-Year Experience and Surgical Outcomes.

The Journal of craniofacial surgery·2026

Same author

Capillary flow-driven paper-based microfluidic sensor for NDMA detection in water.

Lab on a chip·2026

Same author

Integrated Magnetophoretic-Electrochemical platforms for portable detection of HER2 in breast cancer diagnosis.

Biosensors & bioelectronics·2026

Same author

Smartphone-Based Peptide Nucleic Acid (PNA) Probe-Assisted Potentiometric Biosensor for Point-of-Care Testing of SARS-CoV-2 Nucleic Acid.

Analytical chemistry·2026

Same author

Detection of Aerosolized Protein Using a Condensation Growth Tube Coupled with an Electrochemical Immunoassay on Screen-Printed Carbon Electrodes.

Analytical chemistry·2026

Same author

Capillary-Driven Duplex Microfluidic Device Enabling Simultaneous Electrochemical Immunoassays for Detecting SARS-CoV-2 and Respiratory Syncytial Virus.

ACS sensors·2026

Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026

Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026

Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026

Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026

Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026

Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 4, 2026

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Spatiotemporal norepinephrine mapping using a high-density CMOS microelectrode array.

John B Wydallis¹, Rachel M Feeny, William Wilson

¹Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872, USA. chuck.henry@colostate.edu.

|September 4, 2015

Summary

This summary is machine-generated.

This study presents a novel 8192-electrode electrochemical sensor array for high-resolution chemical imaging. The device enables real-time mapping of chemical gradients in complex biological samples with unprecedented spatiotemporal detail.

More Related Videos

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

High-resolution Optical Mapping of the Mouse Sino-atrial Node

High-resolution Optical Mapping of the Mouse Sino-atrial Node

Published on: December 2, 2016

Related Experiment Videos

Last Updated: Apr 4, 2026

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

High-resolution Optical Mapping of the Mouse Sino-atrial Node

High-resolution Optical Mapping of the Mouse Sino-atrial Node

Published on: December 2, 2016

Area of Science:

Electrochemistry
Sensor Technology
Materials Science

Background:

High-density electrode arrays are crucial for detailed chemical analysis.
Existing technologies often lack the spatiotemporal resolution required for complex gradient imaging.
Complementary Metal Oxide Semiconductor (CMOS) fabrication offers miniaturization and integration potential.

Purpose of the Study:

To develop and characterize a high-density amperometric electrode array for electrochemical imaging.
To achieve high spatiotemporal resolution for mapping chemical gradients.
To demonstrate the array's capability in analyzing complex biological media.

Main Methods:

Fabrication of an 8192-electrode platinum array using CMOS processes.
Integration of an on-chip potentiostat for amperometric measurements.
Utilizing poly(dimethylsiloxane) microfluidics for controlled chemical delivery.
Monitoring electrochemical responses to generate heat maps.

Main Results:

Demonstrated ability to measure norepinephrine concentration gradients in tissue culture media.
Achieved temporal resolution of 10 ms for single subarray monitoring.
Enabled full 2 mm × 2 mm area imaging in 64 seconds.
Validated spatiotemporal resolution through monitoring diffusional transport.

Conclusions:

The developed CMOS-based electrode array provides a powerful platform for high-resolution electrochemical imaging.
The system offers significant advancements in analyzing chemical dynamics in complex environments.
This technology has potential applications in neuroscience, diagnostics, and fundamental chemical research.