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Purinergic signaling in scarring

Davide Ferrari1, Roberto Gambari2, Marco Idzko2

  • 1*Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Department of Pneumology, University of Freiburg, Freiburg, Germany; Laboratory of Immunology and Laboratory of Tissue Engineering and Cutaneous Physiopathology, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy; Department of Specialized, Diagnostic, and Experimental Medicine, University of Bologna, Bologna, Italy; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, USA; and Department of Medicine, New York University, New York, New York, USA dfr@unife.it.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|September 4, 2015
PubMed
Summary

Purinergic signaling, involving adenosine and nucleotides, plays a key role in tissue repair and fibrosis. Modulating these pathways offers a novel therapeutic strategy for preventing or reducing fibrotic conditions.

Keywords:
COPDCrohn’s diseaseadenosineextracellular nucleotidesfibrosis

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