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Updated: Apr 4, 2026

Reverse Genetics to Engineer Positive-Sense RNA Virus Variants
Published on: June 9, 2022
From paramutation to human disease: RNA-mediated heredity
Minoo Rassoulzadegan1, François Cuzin1
1Université de Nice Sophia Antipolis, Inserm U1091 - CNRS U7277, 06034 Nice, France.
Abstract:
Epigenetic variation, a stable alteration in gene expression, occurs at multiple moments during development. Several instances of non-Mendelian transmission to the progenies modes are very intriguing. Studies of the mode of hereditary transmission revealed in a series of such cases a role of noncoding RNA molecules as inducers. While still an enigmatic mechanism, emerging models pinpoint to a more general roles of these variations, initiated as a response to genetic and environmental variation. Here we compare the known modes of transgenerational epigenetic variation in mice and humans.
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