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The antiallatal effects on locusts and lethal effects on nematodes of synthetic precocene-1 derivatives differing at
1Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Szeged.
Acta Biologica Hungarica
|January 1, 1989
Abstract:
Fourteen precocene-1 (P1) derivatives differing at C-7 were synthetized and tested for their antiallatal activities on Locusta migratoria (in vitro and in vivo) and nematocidal effects on Caenorhaditis elegans. An outstanding antiallatal effect was produced by 7-propargyloxy-P1 in vitro. It caused an elevated rate of mortality when applied in vivo to locusts or nematodes. The antiallatal effect of 7-cyclopentyloxy-P1 was not accompanied by toxicity. Aralkyloxy substitution at C-7 eliminated the precocene activity.