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Updated: Apr 4, 2026

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
Published on: February 17, 2023
Premature ventricular beats initiate recurrent ventricular fibrillation in early repolarization syndrome
Nauman Ahmed1, Antonio Frontera1, Edward Duncan1
1Level 7, Bristol Heart Institute, Marlborough Street, Bristol BS2 8HW, United Kingdom.
Abstract:
An early repolarization (ER) pattern on electrocardiography was historically considered a benign finding; however, this finding in the inferior and lateral leads has recently been associated with idiopathic ventricular fibrillation (VF). Here we describe a case of a 29-year-old man with an ER pattern, who experienced recurrent implantable cardioverter-defibrillator (ICD) shocks for ventricular tachycardia (VT) and VF. An ICD interrogation demonstrated how VF and VT were repeatedly initiated by closely coupled premature ventricular beats.
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